Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice
نویسندگان
چکیده
منابع مشابه
Chronic intermittent hypoxia/reoxygenation facilitate amyloid-β generation in mice.
Previous studies have shown a high prevalence of obstructive sleep apnea (OSA) among patients with Alzheimer's disease (AD). However, it is poorly assessed whether chronic intermittent hypoxia (CIH), which is a characteristic of OSA, affects the pathophysiology of AD. We aimed to investigate the direct effect of intermittent hypoxia (IH) in pathophysiology of AD in vivo and in vitro. In vivo, 1...
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BACKGROUND Soluble oligomeric (misfolded) species of amyloid-β (Aβ) are the main mediators of toxicity in Alzheimer's disease (AD). These oligomers subsequently form aggregates of insoluble fibrils that precipitate as extracellular and perivascular plaques in the brain. Active immunization against Aβ is a promising disease modifying strategy. However, eliciting an immune response against Aβ in ...
متن کاملCorrection: Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
[This corrects the article DOI: 10.1371/journal.pone.0170345.].
متن کاملAcute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
BACKGROUND Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation through various molecular mechanisms including the up-regulation of the amyloid-β precursor protein, the β-secretase Bace1, or the γγ-secretase complex components, as well as th...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2013
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-130419